Type species: Diplotrypa infida Ulrich, 1886
This genus includes the species:
| Mesotrypa angularis | Ulrich & Bassler, 1904 | Ordovician Sandbian-Katian | USA Kentucky |
| Mesotrypa bulmani | Ross, 1963 | Ordovician Sandbian-Katian | England |
| Mesotrypa bystrowi | Modzalevskaya, 1953 | Ordovician Darriwillian-Katian | Estonia |
| Mesotrypa crustulata | Coryell, 1921 | Ordovician Sandbian-Katian | USA Tennessee |
| Mesotrypa discoidea | Ulrich, 1893 | Ordovician Sandbian-Katian | USA Minnesota |
| Mesotrypa discoidea sibirica | Jaroshinskaya, 1960 | Ordovician Sandbian-Katian | Russia Gornyi Altai |
| Mesotrypa distincta | Parks, 1925 | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa diversa | (Parks & Dyer, 1922) | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa dubia | Coryell, 1921 | Ordovician Sandbian-Katian | USA Tennessee |
| Mesotrypa echinata | Ulrich & Bassler, 1904 | Ordovician Sandbian-Katian | USA Tennessee, Kentucky |
| Mesotrypa egena | Bassler, 1911 | Ordovician Sandbian-Katian | Estonia |
| Mesotrypa esthonica | Astrova, 1970 | Silurian Llandovery | Estonia |
| Mesotrypa excentrica | Modzalevskaya, 1953 | Ordovician Sandbian-Katian | Estonia, Belarus |
| Mesotrypa favosa | Loeblich, 1942 | Ordovician Sandbian-Katian | USA Oklahoma |
| Mesotrypa gutta | Pushkin, 1987 | Ordovician | Belarus |
| Mesotrypa infida | (Ulrich, 1886) | Ordovician Sandbian-Katian | USA Minnesota |
| Mesotrypa lens | (McCoy, 1850) | Ordovician Sandbian-Katian | England, France |
| Mesotrypa macrocellata | Nekhorosheva, 1970 | Ordovician Sandbian-Katian | Russia |
| Mesotrypa maculosa | Caley, 1936 | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa mesoporica | (Pushkin, 1976) | Ordovician Darriwillian | Belarus |
| Mesotrypa mimeta | Fan & Hu, 1985 | Silurian Ludlow | China |
| Mesotrypa nodosa | (Ulrich, 1893) | Ordovician Katian-Hirnantian | USA Wisconsin, Illinois |
| Mesotrypa obliqua | Fritz, 1957 | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa orbiculata | Cumings & Galloway, 1913 | Ordovician Katian-Hirnantian | USA Indiana |
| Mesotrypa orientalis | Bassler, 1911 | Silurian Llandovery | Estonia |
| Mesotrypa parvatrypa | Fritz, 1957 | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa patella | (Ulrich, 1890) | Ordovician Katian-Hirnantian | USA, Canada |
| Mesotrypa pauca | Utgaard & Perry, 1964 | Ordovician Katian-Hirnantian | USA Indiana |
| Mesotrypa piriformis | (Eichwald, 1832) | Ordovician Darriwillian-Katian | Russia |
| Mesotrypa prolifica | Fritz in Parks, 1925 | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa quebecensis | (Ami, 1892) | Ordovician Sandbian-Katian | USA, Canada |
| Mesotrypa raritabulata | Modzalevskaya, 1953 | Ordovician Sandbian-Katian | Russia |
| Mesotrypa regularis | (Foord, 1883) | Ordovician Sandbian-Katian | Canada, USA |
| Mesotrypa? rotunda | Ulrich, 1893 | Ordovician Sandbian-Katian | USA Minnesota |
| Mesotrypa selkirkensis | Whiteaves, 1897 | Ordovician Sandbian-Katian | Canada |
| Mesotrypa? simplex | Fritz, 1926 | Ordovician Sandbian-Katian | Canada Ontario |
| Mesotrypa sparsa | McKinney, 1971 | Ordovician Sandbian-Katian | USA Alabama |
| Mesotrypa? spinosa | Ulrich, 1893 | Ordovician Caradoc=Sandbian-Katian | USA Minnesota |
| Mesotrypa strumaeformis | Pushkin, 1987 | Ordovician | Belarus |
| Mesotrypa suprasilurica | Hennig, 1908 | Silurian Wenlock | Sweden Gotland |
| Mesotrypa torosa | Modzalevskaya, 1953 | Ordovician Darriwillian | Russia |
| Mesotrypa tuberculata | Modzalevskaya, 1953 | Ordovician Sandbian-Katian | Estonia |
| Mesotrypa tubulifera | Loeblich, 1942 | Ordovician Sandbian-Katian | USA Oklahoma |
| Mesotrypa volchovensis | Modzalevskaya, 1953 | Ordovician Darriwillian | Russia |
| Mesotrypa yunnanensis | Hu & Fan, 1985 | Silurian Wenlock | China |
Mesotrypa from Nashville region: at University of Georgia.
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